Thermo Fisher Scientific CD29 (Integrin beta 1) Monoclonal Antibody (eBioHMb1-1 (HMb1-1)), Biotin, eBioscience
CD29(Integrin β1)을 인식하는 Biotin 결합 단클론 항체로, 마우스 및 랫트 시료에 반응합니다. Flow cytometry와 IHC(Frozen)에 적합하며, 세포 부착·이동·분화 연구에 활용됩니다. 0.5 mg/mL 농도의 액상 제품으로 4°C 보관, 동결 금지.
- 카탈로그번호
- 13-0291-80
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | - | View 4 publications |
| Flow Cytometry (Flow) | 0.125 µg/test | View 60 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioHMb1-1 (HMb1-1) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1518777 |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 700
- NovaFluor Red 755
- NovaFluor Yellow 660
- NovaFluor Yellow 700
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 702
- Request custom conjugation
Product Specific Information
Description:
The eBioHMb1-1 monoclonal antibody reacts with mouse and rat CD29 (integrin beta 1), a 110–120 kDa member of the beta integrin family expressed by leukocytes, endothelial, smooth muscle, and epithelial cells. CD29 forms heterodimers with alpha integrins (CD49a–f) to create VLA-1 through VLA-6 complexes, as well as with CD51. These integrins mediate cellular processes such as adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind extracellular matrix proteins (collagen, laminin, fibronectin, vitronectin) and can interact with cellular receptors like VCAM-1 and MadCAM-1.
Applications Reported:
Suitable for flow cytometric analysis and immunohistology staining of frozen tissue sections.
Applications Tested:
Tested by flow cytometric analysis of mouse splenocytes. Recommended ≤0.125 µg/test (100 µL final volume). Cell number should be optimized empirically (10⁵–10⁸ cells/test). Antibody titration is recommended for best performance.
Target Information
ITGB1 (Integrin Subunit Beta 1, CD29):
A 110 kDa cell surface glycoprotein expressed by various cell types including all leukocytes. Forms non-covalent heterodimers with at least six alpha chains (α1–α6), determining VLA integrin binding properties. Functions in cell adhesion, migration, and immune cell trafficking. Expression changes are associated with tumor drug resistance and inflammatory responses. Two major isoforms, β1A and β1D, show tissue-specific distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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