Thermo Fisher Scientific CD31 (PECAM-1) Monoclonal Antibody (390), Biotin, eBioscience
Mouse CD31(PECAM-1) 인식 단클론 항체로, Biotin 결합 형식입니다. Flow cytometry 및 면역분석에 적합하며, endothelial cell 및 leukocyte 표면 단백질 검출에 사용됩니다. 4°C 보관, 동결 금지.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 3 |
| Immunohistochemistry (IHC) | - | 28 |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 3 |
| Immunocytochemistry (ICC/IF) | - | 13 |
| Flow Cytometry (Flow) | 0.25 µg/test | 106 |
| ChIP assay (ChIP) | - | 1 |
| Miscellaneous PubMed (Misc) | - | 3 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Fish, Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 390 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466419 |
Additional Formats Available
- Unconjugated
- APC
- Brilliant UV 661
- Brilliant UV 737
- Brilliant Violet 421
- Brilliant Violet 711
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 710
- NovaFluor Red 725
- NovaFluor Red 755
- NovaFluor Yellow 610
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The 390 monoclonal antibody reacts with mouse CD31 (platelet-endothelial cell adhesion molecule-1, PECAM-1, gpIIa). This 130–140 kDa surface protein is expressed by endothelial cells and at low levels on all leukocytes and platelets. CD31 participates in adhesion, cell-cell and cell-matrix interactions, and signal transduction.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested on mouse thymocytes and splenocytes, ≤0.25 µg/test in 100 µL volume. Optimal antibody titration is recommended.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD31 (PECAM-1) is an inhibitory coreceptor regulating T and B cell signaling through ITIM motifs that recruit protein-tyrosine phosphatases upon phosphorylation. It is expressed throughout the vascular system, mainly at intercellular junctions. The N-terminal Ig-like domain mediates homophilic binding, critical for cell-cell interaction.
CD31 functions in:
- Integrin-mediated adhesion
- Transendothelial migration
- Angiogenesis
- Apoptosis regulation
- Negative regulation of immunoreceptor signaling
- Autoimmunity and macrophage phagocytosis
- IgE-mediated anaphylaxis and thrombosis
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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