Thermo Fisher Scientific CD100 Recombinant Rabbit Monoclonal Antibody (121)

Applications and Tested Dilution

• Application: ELISA
• Tested Dilution: 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. To prevent contamination, it is recommended to add sodium azide (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to the large rabbit immune repertoire

This antibody specifically recognizes Mouse Semaphorin 4D/SEMA4D/CD100.

Target Information

Semaphorins are neuronal chemorepellants that guide pioneering neurons during nervous system development.
CD100 (Semaphorin 4D) is a 150 kDa homodimer that induces B cell aggregation and enhances viability in vitro. It modulates CD40–CD40L signaling by promoting B cell aggregation and survival while downregulating CD23 expression.

CD72 acts as a lymphocyte receptor for CD100 and participates in regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells, weakly on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T and B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.