Thermo Fisher Scientific CNOT7 Recombinant Rabbit Monoclonal Antibody (2H45L49)
CNOT7 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot에 적합합니다. 인간 반응성을 가지며 마우스, 랫, 소에서도 반응 예측됩니다. 고순도 Protein A 정제, 액상 형태로 제공되며 안정적인 저장 조건을 유지합니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2H45L49 |
| Immunogen | Protein corresponding to human CNOT7 [aa1–aa285] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2809250 |
Product Specific Information
This antibody is predicted to react with Mouse, Rat, and Bovine.
Target Information
CNOT7 (CCR4-NOT transcription complex subunit 7) has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8.
CNOT7 is a catalytic component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases, and is linked to various cellular processes including:
- Bulk mRNA degradation
- miRNA-mediated repression
- Translational repression during initiation
- General transcription regulation
During miRNA-mediated repression, the complex may act as a transcriptional repressor during translational initiation.
CNOT7 associates with BTG family members such as TOB1 and BTG2 and is required for their anti-proliferative activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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