Thermo Fisher Scientific E6AP Recombinant Rabbit Monoclonal Antibody (19H14L13)
E6AP 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot에 적합합니다. Expi293 시스템에서 발현되었으며, 높은 특이성과 일관된 품질을 제공합니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 19H14L13 |
| Immunogen | Protein corresponding to human E6AP [aa50–aa200] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809249 |
Product Specific Information
This antibody is predicted to react with Monkey, Pig, Sheep, and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
Target: UBE3A (ubiquitin-protein ligase E3A, also known as E6AP)
UBE3A is an E3 ubiquitin-protein ligase that transfers ubiquitin from an E2 enzyme to its substrates. Identified substrates include ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, PML tumor suppressor, and CDKN1B.
UBE3A may function in cellular quality control by aiding degradation of misfolded cytoplasmic proteins and plays a role in circadian clock regulation.
Defects in UBE3A are associated with Angelman syndrome (AS).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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