Thermo Fisher Scientific COMMD1 Monoclonal Antibody (OTI1F2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

COMMD1 is a proposed scaffold protein involved in various physiological processes, including regulation of ubiquitination of specific cellular proteins. It modulates cullin-RING E3 ubiquitin ligase (CRL) activity by displacing CAND1 and promotes ubiquitination and degradation of NF-κB subunit RELA, thereby down-regulating NF-κB activity.

COMMD1 also regulates membrane expression and ubiquitination of SLC12A2 and epithelial Na⁺ channel (ENaC) subunits, influencing Na⁺ transport. It promotes CFTR cell surface expression via ubiquitination control and modulates SOD1 activity by interfering with its homodimerization. Additionally, COMMD1 plays a key role in copper ion homeostasis, ATP7A trafficking, and HIF1A-mediated transcription regulation.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.