Thermo Fisher Scientific Neuropilin-1 Polyclonal Antibody
Neuropilin-1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에 적합합니다. Human 및 Bovine 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. VEGF 유도 혈관신생 연구 및 신경계 발달 관련 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide surrounding the epitope -LNTQS- (without phosphorylation site at Thr916) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human brain tissue
- Cellular location: Cytoplasmic, membrane
Target Information
Neuropilin 1 is a 923 amino acid membrane-bound coreceptor belonging to the neuropilin family, containing two CUB domains, two F5/8 type C domains, and a MAM domain. It forms heterodimers with Neuropilin 2 (NRP2) and binds to plexin (PLXNB1) to form semaphorin receptors.
Expressed primarily in the nervous system, Neuropilin 1 plays roles in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, neuronal migration, and organogenesis.
It functions as a receptor for semaphorins and vascular endothelial growth factor (VEGF) and regulates VEGF-induced angiogenesis. Neuropilin 1 is also implicated in advanced prostate carcinoma and breast cancer progression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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