Thermo Fisher Scientific TRIB1 Polyclonal Antibody
TRIB1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot에 최적화되어 있으며, 인간 및 서열 상 유사한 생물종에서 반응이 예측됩니다. KLH 접합 합성 펩타이드로 면역화되었으며, 액상 형태로 보관 및 취급이 용이합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 341–370 amino acids from the C-terminal region of human TRIB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2209076 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
TRIB1, also known as gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities.
Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity.
TRIB1 inhibited oncogenic Ras-driven AP1 activation and MEKK1-mediated AP1 activation, while enhancing ERK activation.
Coimmunoprecipitation and yeast 2-hybrid assays showed interactions between MEK1 and TRIB1/TRIB3, and MKK4 interacted specifically with TRIB1.
Cotranfection of MKK4 enhanced TRIB1 levels, indicating that TRIB-MAPKK interaction stabilizes TRIB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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