Thermo Fisher Scientific MICA/B Monoclonal Antibody (6D4), APC
인간 MICA/B 단백질을 인식하는 마우스 단클론 항체로, APC 형광체가 결합되어 있습니다. Flow Cytometry에 적합하며, CD314(NKG2D) 매개 NK 및 T세포 활성화를 차단할 수 있습니다. 4°C 암소 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D4 |
| Immunogen | Transfected C1R cells expressing MICA |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898637 |
Additional Formats
- Alexa Fluor 647
- Alexa Fluor 700
- Biotin
- FITC
- PE-Cyanine7
- Custom conjugation available
Product Specific Information
This antibody recognizes a common extracellular epitope on MICA and MICB glycoproteins, which are transmembrane ligands of CD314 (NKG2D). It can block CD314-mediated activation of NK cells and cytotoxic T cells.
Target Information
MICA encodes the highly polymorphic MHC (HLA) class I chain-related gene A. The protein is expressed on the cell surface but does not associate with beta-2-microglobulin like canonical class I molecules. MICA functions as a stress-induced antigen recognized by intestinal epithelial gamma delta T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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