Thermo Fisher Scientific CD11b Monoclonal Antibody (MEM-174), FITC
인간 CD11b 항원을 인식하는 Mouse IgG2a 단클론 항체로, FITC 형광 표지되어 Flow Cytometry에 적합합니다. CD11b는 면역세포 표면 접착 분자로, 단핵구·과립구·NK세포 분석에 활용됩니다. 4°C 암조건 보관, PBS/BSA 완충액에 용해된 액상 형태입니다.
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Thermo Fisher Scientific CD11b Monoclonal Antibody (MEM-174), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 20 µL / 1×10⁶ cells
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-174 |
| Immunogen | Human granulocytes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark. Do not freeze. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071193 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD11b antigen (Mac-1 alpha), a 165–170 kDa type I transmembrane protein mainly expressed on monocytes, granulocytes, and NK cells. CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3).
CD11b is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, NK cells, dendritic cells, and microglia. It functions as a receptor for ICAM-1, ICAM-2, ICAM-4, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X—critical for cell-cell and cell-matrix interactions.
CD11b expression varies by tissue and cell type and is commonly used as a microglial marker. Dysregulation is associated with systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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