Thermo Fisher Scientific CD11b Monoclonal Antibody (MEM-174), FITC

Thermo Fisher Scientific CD11b Monoclonal Antibody (MEM-174), FITC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 20 µL / 1×10⁶ cells
  View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD11b antigen (Mac-1 alpha), a 165–170 kDa type I transmembrane protein mainly expressed on monocytes, granulocytes, and NK cells. CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.

Target Information

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3).
CD11b is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, NK cells, dendritic cells, and microglia. It functions as a receptor for ICAM-1, ICAM-2, ICAM-4, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X—critical for cell-cell and cell-matrix interactions.
CD11b expression varies by tissue and cell type and is commonly used as a microglial marker. Dysregulation is associated with systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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