
Thermo Fisher Scientific CD11a Monoclonal Antibody (MEM-25), FITC
인간 CD11a 항원을 인식하는 FITC 결합 단클론 항체로, 유세포분석(Flow Cytometry)에 적합합니다. LFA-1 복합체의 α-서브유닛을 표적하며, 면역세포 부착 및 활성화 연구에 활용됩니다. 액상 형태로 제공되며 4°C에서 보관합니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
- View 4 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-25 |
| Immunogen | Leucocytes from a patient suffering from a LGL type leukaemia |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071168 |
Additional Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- Biotin
- PE
- Request custom conjugation
Product Specific Information
This antibody reacts with an extracellular epitope of CD11a (alpha subunit of human LFA-1), a 170–180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils, and eosinophils.
Target Information
CD11a (LFA-1 alpha, ITGAL) forms part of the leukocyte function-associated antigen 1 (LFA-1) complex with CD18 (αLβ2 integrin).
It plays a crucial role in leukocyte adhesion and signaling through interactions with ICAM-1, ICAM-2, and ICAM-3.
CD11a participates in immune cell interactions, tissue-specific localization, and regulation of T-cell effector functions.
Blocking CD11a activity is a therapeutic strategy in inflammatory diseases, as demonstrated by the anti-CD11a antibody Efalizumab (Raptiva).
Two transcript variants encoding different isoforms of CD11a are known. Dysfunctions are associated with benign cephalic histiocytosis and leukocyte adhesion deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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