Thermo Fisher Scientific CD11a Monoclonal Antibody (MEM-25), FITC

Applications

• Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
• View 4 publications

Product Specifications

Additional Available Formats

• Unconjugated
• Alexa Fluor 700
• APC
• Biotin
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD11a (alpha subunit of human LFA-1), a 170–180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils, and eosinophils.

Target Information

CD11a (LFA-1 alpha, ITGAL) forms part of the leukocyte function-associated antigen 1 (LFA-1) complex with CD18 (αLβ2 integrin).
It plays a crucial role in leukocyte adhesion and signaling through interactions with ICAM-1, ICAM-2, and ICAM-3.
CD11a participates in immune cell interactions, tissue-specific localization, and regulation of T-cell effector functions.
Blocking CD11a activity is a therapeutic strategy in inflammatory diseases, as demonstrated by the anti-CD11a antibody Efalizumab (Raptiva).
Two transcript variants encoding different isoforms of CD11a are known. Dysfunctions are associated with benign cephalic histiocytosis and leukocyte adhesion deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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