Thermo Fisher Scientific CD206 Monoclonal Antibody (15-2)

Applications and Tested Dilution

Product Specifications

Additional Formats

• Alexa Fluor 647
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162–175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes.

Target Information

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. It is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells, and sperm cells. CD206 plays a key role in innate and adaptive immune responses and mediates recognition and uptake of macromolecules such as modified lipoproteins, advanced glycation end products (AGEs), and amyloid β-protein (Aβ).

CD206 expression is linked to processes including cell adhesion, host defense, atherosclerosis, and amyloid β deposition in Alzheimer’s disease. The CD206 gene encodes class A macrophage scavenger receptors, with three isoforms (1, 2, 3) generated by alternative splicing. Isoforms 1 and 2 mediate endocytosis of modified LDLs, while isoform 3 lacks this function and can inhibit the activity of the others, suggesting a regulatory role in macrophage receptor activity. CD206 dysfunction is associated with diseases such as leprosy and Gaucher’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.