Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (ER506), PE
인간 Estrogen Receptor α(ERα)를 인식하는 단클론 항체로, PE 형광표지되어 ICC/IF 및 Flow Cytometry에 적합합니다. 높은 특이성과 재현성을 제공하며, 단백질 A/G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (ER506), PE
Applications
- Immunocytochemistry (ICC/IF): 1:50–1:100
- Flow Cytometry (Flow): 5 µL/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ER506 |
| Immunogen | Recombinant human Estrogen Receptor alpha protein (aa 2–185) |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
Additional Formats
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. This interaction regulates gene transcription through recruitment of coactivator or corepressor proteins.
There are two main forms of the estrogen receptor, alpha (ESR1) and beta (ESR2), encoded by separate genes. Alternative RNA splicing produces at least four alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are widely expressed and play essential roles in sexual development, reproductive function, bone metabolism, and are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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