Thermo Fisher Scientific LGP2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL
• Suggested positive control: Rat kidney tissue lysate
• Blocking peptide: PEP-0552

Product Specifications

Target Information

Anti-viral innate immune responses are triggered by pathogen-associated molecular patterns, such as intracellular nucleic acids resulting from viral infections. These responses represent the first line of defense against infectious organisms. Toll-like receptors (TLR3, 7, 8, 9) detect foreign nucleic acids as transmembrane pattern recognition receptors in immune cells.
RIG-I and MDA5, members of the CARD-helicase family, perform similar roles in the cytoplasm. LGP2 is structurally related to RIG-I and MDA5 but lacks a CARD domain, suggesting it functions as a negative-feedback regulator in intracellular antiviral signaling. At least four isoforms of LGP2 have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.