Thermo Fisher Scientific TEM7 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• A suggested positive control is rat liver tissue lysate.
• PA5-20428 can be used with blocking peptide PEP-0545.

Target Information

Using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al. identified 46 genes with elevated expression in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC) and named Tumor Endothelial Markers (TEMs, TEM1–9).
TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, and primary cancers of lung, pancreas, breast, and brain. TEM7 expression is consistent across both primary and metastatic cancers. Other family members (TEM1, 3, 4, 5, 8, 9) show similar expression patterns in lung and brain tumors, and liver metastasis.
Since many of the genes differentially expressed in tumor endothelium are also expressed during angiogenesis, these genes may provide important resources for basic and clinical studies of human angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.