Thermo Fisher Scientific CDNF Polyclonal Antibody
CDNF 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품이며, 1 mg/mL 농도. 파킨슨병 연구 등 신경영양 인자 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 12 amino acid peptide from near the amino terminus of human CDNF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155634 |
Product Specific Information
- Suggested positive control: A-20 cell lysate
- PA5-20430 can be used with blocking peptide PEP-0547
Target Information
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and is highly homologous to the mesencephalic astrocyte-derived neurotrophic factor.
CDNF is expressed at higher levels in tissues such as heart, skeletal muscle, and testes than in the brain.
Similar to GDNF, CDNF can prevent 6-hydroxydopamine (6-OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease.
CDNF can also restore dopaminergic function and prevent neuron degeneration in the substantia nigra, suggesting potential therapeutic use for Parkinson’s disease.
At least two isoforms of CDNF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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