Thermo Fisher Scientific ALX4 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRAFPGG DKFGTTFLSA
• Sequence homology: Cow 93%; Dog 93%; Guinea Pig 93%; Human 100%; Mouse 93%; Rabbit 93%; Rat 93%

Target Information

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue.
Mutations in this gene cause parietal foramina 2 (PFM2), an autosomal dominant disease characterized by deficient ossification of the parietal bones.
Mutations also cause a form of frontonasal dysplasia with alopecia and hypogonadism, suggesting a role in craniofacial development, mesenchymal-epithelial communication, and hair follicle development.
Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS), characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males.
In mouse, this gene uses dual translation initiation sites located 16 codons apart.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.