Thermo Fisher Scientific CD74 Recombinant Mouse Monoclonal Antibody (LL1 (EPB1))

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity: This antibody reacts with the cell surface epitope of the invariant chain (Ii) subunit of the immature MHC class-II antigen CD74.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The alpha chain gene contains 5 exons:

• Exon 1 encodes the leader peptide
• Exons 2 and 3 encode the two extracellular domains
• Exon 4 encodes the transmembrane domain and cytoplasmic tail

DRA does not have polymorphisms in the peptide-binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5.
Within the DR molecule, the beta chain contains all polymorphisms specifying peptide-binding specificities.
Hundreds of DRB1 alleles have been described, and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
Three loci—DR, DQ, and DP—encode the major expressed products of the human class II region.
Human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and play a critical role in initiating the immune response.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.