Thermo Fisher Scientific CD11b Polyclonal Antibody
Human CD11b 단백질을 인식하는 염소 폴리클로날 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합. ITGAM 내부 서열을 면역원으로 사용. 고순도 액상 형태로 제공되며 -20°C 보관. 연구용 전용 시약.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 6–8 µg/mL | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RNDGEDSYRTQ) corresponding to internal amino acids of ITGAM (aa 807–818) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10977861 |
Product Specific Information
- Predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that non-covalently associates with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex—also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3)—is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, subsets of NK and dendritic cells, and microglia.
It functions as a receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X, mediating critical cell–cell and cell–matrix interactions.
CD11b expression varies by cell type and tissue, commonly used as a microglial marker in nervous tissue. Elevated expression is observed during monocyte maturation, with peritoneal macrophages showing higher levels than splenic macrophages.
Dysfunction of CD11b is associated with systemic lupus erythematosus and ITGAM-related autoimmune susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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