Thermo Fisher Scientific Alpha-2-Macroglobulin/A2M Monoclonal Antibody (A2M/6556)
인간 A2M 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, IHC 및 Peptide Array 등 다양한 분석에 적합. 단백질 A/G로 정제된 액상형 제품이며, 보존제가 포함되지 않음. -20°C에서 보관하며 연구용으로 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2M/6556 |
| Immunogen | Human recombinant A2M protein fragment (around aa 604–748) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alpha 2-Macroglobulin (A2M) is an approximately 720-kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits. A2M shares structural and functional similarities with other alpha-macroglobulins such as complement components C3, C4, and pregnancy zone protein (PZP), exhibiting a broad ligand-binding capacity. This property enables A2M to function as a humoral defense barrier against foreign peptides in plasma. A2M acts as a panprotease inhibitor, capturing various proteinases. In Alzheimer’s disease patients, A2M has been localized in diffuse amyloid plaques, suggesting its role in AD pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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