Thermo Fisher Scientific Alpha-2-Macroglobulin Monoclonal Antibody (A2M/3622)
인간 Alpha-2-Macroglobulin을 인식하는 단클론 항체로, IHC 및 Peptide Array에 사용 가능. Mouse IgG2b 아이소타입이며, Protein A/G로 정제된 액상 형태. 4°C에서 보관하며 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2M/3622 |
| Immunogen | Human recombinant A2M protein fragment (amino acids 604–748) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Alpha 2-Macroglobulin (A2M) is an approximately 720-kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits. It shares structural and functional similarities with other alpha-macroglobulins such as complement components C3, C4, and pregnancy zone protein (PZP), exhibiting a remarkable ability to bind a wide range of ligands. This enables alpha-macroglobulins to act as humoral defense barriers against foreign peptides in plasma. A2M functions as a broad-spectrum protease inhibitor and has been localized to diffuse amyloid plaques in the brains of Alzheimer’s disease patients, suggesting an important role in AD pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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