Thermo Fisher Scientific Alpha-2-Macroglobulin Monoclonal Antibody (A2M/3622)
Alpha-2-Macroglobulin 단백질을 인식하는 Mouse monoclonal antibody. 인체 시료에 반응하며 IHC(P) 및 Peptide Array에 사용 가능. Protein A/G 정제, 4°C 보관, 24개월 안정성 보유. 연구용 전용 시약.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A2M/3622 |
| Immunogen | Human recombinant A2M protein fragment (around aa 604–748) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human liver or placenta tissues
- Cellular Localization: Secreted in plasma
Target Information
Alpha 2-Macroglobulin (A2M) is an approximately 720-kDa homotetrameric glycoprotein composed of four identical ~180 kDa subunits.
It shares structural and functional similarities with other alpha-macroglobulins such as complement components C3, C4, and pregnancy zone protein (PZP).
A2M binds a wide range of ligands and acts as a humoral defense barrier against foreign peptides in plasma.
It interacts with and captures various proteinases, functioning as a panprotease inhibitor.
In Alzheimer’s disease (AD) patients, A2M has been localized to diffuse amyloid plaques, suggesting a role in AD pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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