Thermo Fisher Scientific CD105 Monoclonal Antibody (MEM-226), FITC
CD105(Endoglin) 단백질을 인식하는 FITC 결합 Mouse Monoclonal Antibody. 인간 및 랫트 시료에 반응하며 Flow Cytometry에 적합. 액상 형태로 제공되며 PBS/BSA 버퍼에 보관. 암혈관 및 증식성 내피세포 연구용으로 활용 가능.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 20 µL / 1×10⁶ cells
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-226 |
| Immunogen | Recombinant vaccinia virus containing the human CD105 cDNA |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071125 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Target Information
CD105 (Endoglin) is a Type I transmembrane protein highly expressed on human vascular endothelial cells. It forms an O- and N-glycosylated homodimer. Upregulation of endoglin expression is observed in tumor vasculature and proliferating cells, indicating its role as a proliferation-associated endothelial marker. CD105 binds TGF beta 1 and 3 with high affinity but not TGF beta 2.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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