Thermo Fisher Scientific CD105 Monoclonal Antibody (MEM-226), FITC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 20 µL / 1×10⁶ cells
  View 9 publications

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Target Information

CD105 (Endoglin) is a Type I transmembrane protein highly expressed on human vascular endothelial cells. It forms an O- and N-glycosylated homodimer. Upregulation of endoglin expression is observed in tumor vasculature and proliferating cells, indicating its role as a proliferation-associated endothelial marker. CD105 binds TGF beta 1 and 3 with high affinity but not TGF beta 2.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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