Thermo Fisher Scientific CD46 Monoclonal Antibody (MEM-258), FITC
CD46 단백질을 인식하는 FITC 결합 마우스 단클론 항체. 인간 및 소 반응성. 세포 표면 CD46 검출용으로 유세포분석(Flow Cytometry)에 적합. 4°C 어둡게 보관, 동결 금지. 연구용 전용.
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Applications
- Flow Cytometry (Flow): 20 µL/100 µL whole blood
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-258 |
| Immunogen | T cell line HPB-ALL |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072491 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- Biotin
- PE
- Custom conjugation available
Product Specific Information
This antibody recognizes an extracellular epitope on the SCR4 (membrane-proximal SCR) domain of CD46 (Membrane cofactor protein).
CD46 is a 56–66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells, and fibroblasts; it is negative on erythrocytes.
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments. It regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction.
CD46 also serves as a receptor for several human pathogens (bacteria and viruses) and influences T lymphocyte polarization toward antigen-presenting or target cells, modulating immune function.
It protects placental tissue and is expressed on the inner acrosomal membrane of spermatozoa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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