Thermo Fisher Scientific CYP27A1 Polyclonal Antibody
CYP27A1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며 인간, 생쥐, 랫드 반응성 확인. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, 콜레스테롤 대사 연구에 활용 가능.
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Thermo Fisher Scientific CYP27A1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 154–460 of Human CYP27A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545422 |
Product Specific Information
- Recommended positive controls: A549, mouse liver, rat liver
- Predicted reactivity: Pig (83%), Rabbit (83%), Rhesus Monkey (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways. It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol. In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol, whereas in the classic or neutral pathway, it produces 3β-hydroxy-5-cholestenoic acid. It is also involved in the metabolism of vitamin D3.
While CYP27A1 is present in many different tissues, its function in these tissues is largely uncharacterized. In macrophages, 27-hydroxycholesterol generated by this enzyme may help reduce inflammatory factors associated with cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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