Thermo Fisher Scientific XRCC1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 480-633 of human XRCC1 (NP_0062882) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:XRCC1,uniProtId:P18887-1,ncbiNodeId:9606,antigenRange:480-633,antigenLength:633,antigenImageFileName:PA5-87439_XRCC1_P18887-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87439_XRCC1_P18887-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.58 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804148

Product Specific Information

Immunogen sequence: NGAEDSGDTE DELRRVAEQK EHRLPPGQEE NGEDPYAGST DENTDSEEHQ EPPDLPVPEL PDFFQGKHFF LYGEFPGDER RKLIRYVTAF NGELEDYMSD RVQFVITAQE WDPSFEEALM DNPSLAFVRP RWIYSCNEKQ KLLPHQLYGV VPQA

Positive Samples: Mouse liver, Mouse kidney; Cellular Location: Nucleus

Target Information

XRCC1 (X-ray cross complementing factor-1) is involved in DNA base excision repair. XRCC1 is a 70 kDa protein that has been shown to be physically associated with other DNA repair enzymes, including poly (ADP-ribose) polymerase (PARP), DNA Ligase III and DNA polymerase beta. XRCC1 contains a BRCT domain (for BRCA1 carboxyl terminus) which was originally found in the tumor suppressor protein BRCA1. Recently, the BRCT domain has been shown to mediate the protein-protein interaction of XRCC1 and DNA ligase III-alpha.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.