Thermo Fisher Scientific PSEN2 Polyclonal Antibody
PSEN2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, Alzheimer’s disease 관련 연구에 유용합니다. 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PSEN2 (Accession P49810), corresponding to amino acid residues K306–E356 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900428 |
Product Specific Information
This antibody detects endogenous levels of total Presenilin 2.
Target Information
Mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP) are linked to inherited forms of Alzheimer’s disease (AD). These mutations increase production of the longer amyloid-beta form, a major component of amyloid deposits in AD brains. Presenilins are believed to regulate APP processing via gamma-secretase activity and may also influence Notch receptor cleavage. Two alternatively spliced transcript variants encoding different PSEN2 isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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