Thermo Fisher Scientific AMPK alpha-2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human AMPK alpha-2 (PRKAA2). Validated for Western blot. Detects endogenous total PRKAA2. Supplied unconjugated in liquid form, affinity purified, and stored in PBS with glycerol. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKAA2 (Accession P54646), corresponding to amino acid residues L363–Y413 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900429 |
Product Specific Information
Antibody detects endogenous levels of total PRKAA2.
Target Information
The protein encoded by this gene is a catalytic subunit of AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits. It acts as an energy-sensing enzyme that monitors cellular energy status. Upon metabolic stress, AMPK becomes activated and phosphorylates acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), key regulators of fatty acid and cholesterol biosynthesis. Studies in mice suggest this subunit controls insulin sensitivity and myocardial energy homeostasis during ischemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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