Thermo Fisher Scientific Integrin beta 7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1 µg/mL

-

Flow Cytometry (Flow)

2.5 µg per million cells

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHO-derived recombinant mouse Integrin beta 7 Glu20-His722 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Integrin beta 7,uniProtId:P26011-1,ncbiNodeId:10090,antigenRange:20-722,antigenLength:806,antigenImageFileName:PA5-47440_Integrin_beta_7_P26011-1_Goat.svg,antigenImageFileNamePDP:PA5-47440_Integrin_beta_7_P26011-1_Goat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609112

Product Specific Information

In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant mouse (rm) Integrin beta 1, rmIntegrin beta 2, recombinant human Integrin beta 3, and rmIntegrin beta 6 is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.