Thermo Fisher Scientific Integrin beta 7 Polyclonal Antibody
마우스 Integrin beta 7 단백질을 인식하는 산양 유래 폴리클로날 항체로, Western blot 및 유세포분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. 낮은 교차 반응성과 높은 특이성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHO-derived recombinant mouse Integrin beta 7 (Glu20–His722) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609112 |
Product Specific Information
- In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant mouse Integrin beta 1, beta 2, recombinant human Integrin beta 3, and mouse Integrin beta 6 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin (LPAM-1), expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin (HML-1), expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes.
Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1, and fibronectin, while the ligand of HML-1 is E-cadherin (CD324).
Integrin beta 7 plays an important role in leukocyte adhesion to endothelial cells, facilitating transmigration into extravascular spaces during inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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