Thermo Fisher Scientific CDCA2 Polyclonal Antibody
CDCA2 단백질을 표적으로 하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 세포주기 및 암 연구에 활용 가능합니다.
- 카탈로그번호
- PA575984
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 525–569 of Human CDCA2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719712 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using epitope-specific immunogen.
Purity is greater than 96% as determined by SDS-PAGE.
Target Information
Cell division cycle associated 2 (CDCA2, also known as Repo-Man) is a cell-cycle protein that recruits protein phosphatase 1 (PP1) to mitotic chromatin at anaphase onset, which is essential for cell proliferation.
Phosphorylation and dephosphorylation of CDCA2 regulate its localization and interaction with PP1.
The CDCA2/PP1 complex is required for chromatin binding, histone H3 dephosphorylation, and nuclear envelope reformation during mitotic exit.
CDCA2 is also implicated in DNA repair and may contribute to cancer progression.
Elevated CDCA2 expression has been observed in various cancers, including melanoma, neuroblastoma, squamous cell carcinoma, and synovial sarcoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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