Thermo Fisher Scientific c-Mpl Monoclonal Antibody (1D6B7)
Thermo Fisher Scientific의 c-Mpl Monoclonal Antibody (1D6B7)는 인간 CD110 단백질을 인식하는 마우스 IgG2a 항체로, Western blot, Flow cytometry, ELISA에 적합합니다. Protein G로 정제된 액상 형태이며, 연구용으로 사용됩니다.
- 카탈로그번호
- MA531670
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D6B7 |
| Immunogen | Purified recombinant fragment of human CD110 (AA: extra 26–175) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787294 |
Product Specific Information
MA5-31670 has been tested in indirect ELISA.
Target Information
In 1990, the oncogene v-mpl was identified from the murine myeloproliferative leukemia virus, capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992, the human homologue c-mpl was cloned, encoding a protein homologous with members of the hematopoietic receptor superfamily. Anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, cloned in 1994, was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by c-mpl, CD110, is a 635 amino acid transmembrane domain with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice are severely thrombocytopenic, emphasizing the role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin, CD110 dimerizes, activating JAK, STAT, MAPK families, adaptor protein Shc, and receptor tyrosine phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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