Thermo Fisher Scientific CaMKII gamma Monoclonal Antibody (8G10C1)

Thermo Fisher Scientific CaMKII gamma Monoclonal Antibody (8G10C1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-31665 has been tested in indirect ELISA.

Target Information

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle.
In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling.
Participates in the modulation of skeletal muscle function in response to exercise.
In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin and phospholamban (PLN/PLB).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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