Thermo Fisher Scientific IDO Recombinant Rabbit Monoclonal Antibody (7H8L17)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Horse, and Goat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to the larger rabbit immune repertoire

Target Information

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of key regulatory molecules such as tryptophan, serotonin, and melatonin. This reaction initiates the production of biologically active metabolites known as kynurenines.

IDO1 is expressed in various human tissues, macrophages, and dendritic cells (DCs). During inflammation, interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense by degrading tryptophan and inhibiting the growth of viruses, bacteria, and parasites. Additionally, IDO1 plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.