Thermo Fisher Scientific NUAK2 Monoclonal Antibody (378CT15.4.5)
Human NUAK2 단백질을 인식하는 Mouse IgM 단일클론 항체. Western blot에 적합하며, 세포 스트레스 및 대사 연구에 활용 가능. 2 mg/mL 농도의 액상 형태로 제공되며, 단기 4°C 보관 및 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 378CT15.4.5 |
| Immunogen | Purified His-tagged NUAK2 protein (fragment) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Euglobulin precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897475 |
Target Information
NUAK2 (also known as SNF1/AMP kinase-related kinase, SNARK) is a member of the NUAK family of SNF1-like kinase 2. It is activated by muscle contraction and mediates contraction-stimulated glucose transport in skeletal muscle. NUAK2 plays a role in cellular stress responses associated with obesity and type 2 diabetes. It exhibits kinase activity against synthetic test peptides, and activity in keratinocytes is increased by AMP and 5-amino-4-imidazolecarboxamide riboside, indicating activation through an AMPK kinase-dependent pathway. Glucose deprivation also enhances NUAK2 activity in baby hamster kidney fibroblasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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