Thermo Fisher Scientific EDG3 Monoclonal Antibody (2G11)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

3 µg/mL

-

ELISA (ELISA)

0.3 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2G11

Immunogen

EDG3 (NP_005217.2, 302 a.a. approximately 378 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:EDG3,uniProtId:Q99500-1,ncbiNodeId:9606,antigenRange:302-378,antigenLength:378,antigenImageFileName:H00001903-M02_EDG3_Q99500-1_House_mouse.svg,antigenImageFileNamePDP:H00001903-M02_EDG3_Q99500-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: SKEMRRAFFR LVCNCLVRGR GARASPIQPA LDPSRSKSSS SNNSSHSPKV KEDLPHTAPS SCIMDKNAAL QNGIFCN

Target Information

EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.