Thermo Fisher Scientific EDG3 Monoclonal Antibody (2G11)
인간 EDG3 단백질을 인식하는 Mouse monoclonal antibody로 IHC(P) 및 ELISA에 사용됩니다. EDG-3는 sphingosine-1-phosphate 수용체로 세포 성장, 분화, 생존 조절에 관여합니다. 친화 크로마토그래피 정제, PBS buffer 보존, 연구용 전용입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G11 |
| Immunogen | EDG3 (NP_005217.2, 302–378 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SKEMRRAFFR LVCNCLVRGR GARASPIQPA LDPSRSKSSS SNNSSHSPKV KEDLPHTAPS SCIMDKNAAL QNGIFCN
Target Information
EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids.
The ligand for EDG-3 is sphingosine-1-phosphate.
There are 8 known members of the EDG receptor family, implicated in mediating growth-related effects such as:
- Induction of cellular proliferation
- Alterations in differentiation and survival
- Suppression of apoptosis
They also evoke cellular effector functions dependent on cytoskeletal responses such as contraction, secretion, adhesion, and chemotaxis.
EDG receptors are developmentally regulated and differ in tissue distribution.
They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several protein tyrosine kinases.
EDG-3 is expressed in cardiovascular, leukocyte-containing, and other tissues.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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