Thermo Fisher Scientific EDG3 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Flow Cytometry (Flow)

• Tested Dilution: 1×10^6 cells / 50 µL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC SFIVLENLMV LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG KKTFSLSPTV WFLREGSMFV ALGASTCSLL AIAIERHLTM IKMRPYDANK RHRVFLLIGM CWLIAFTLGA LPILGWNCLH NLPDCSTILP LYSKKYIAFC ISIFTAILVT IVILYARIYF LVKSSSRKVA NHNNSERSMA LLRTVVIVVS VFIACWSPLF ILFLIDVACR VQACPILFKA QWFIVLAVLN SAMNPVIYTL ASKEMRRAFF RLVCNCLVRG RGARASPIQP ALDPSRSKSS SSNNSSHSPK VKEDLPHTAP SSCIMDKNAA LQNGIFCN

Target Information

EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids.
The ligand for EDG-3 is sphingosine-1-phosphate.
There are 8 known members of the EDG receptor family, implicated in mediating growth-related effects such as:

• Induction of cellular proliferation
• Alterations in differentiation and survival
• Suppression of apoptosis

They also evoke cellular effector functions dependent on cytoskeletal responses such as:

• Contraction
• Secretion
• Adhesion
• Chemotaxis

EDG receptors are developmentally regulated and differ in tissue distribution.
They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several protein tyrosine kinases.
EDG-3 is expressed in cardiovascular, leukocyte-containing, and other tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.