Thermo Fisher Scientific DAP3 Monoclonal Antibody (OTI1B12)
DAP3 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, 인간 시료에 반응하며 WB와 IHC(P) 실험에 사용 가능. 고순도 액상 제품으로 안정적인 PBS/BSA/glycerol 버퍼에 보존. 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 161–398 of DAP3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724191 |
Target Information
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist in protein synthesis within mitochondria. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit, with approximately 75% protein to rRNA composition, unlike prokaryotic ribosomes. The mammalian mitoribosome lacks 5S rRNA and varies significantly among species in protein sequence and biochemical properties.
The DAP3 gene encodes a 28S subunit protein involved in apoptotic pathways initiated by TNF-α, Fas ligand, and interferon-γ. This protein may bind ATP/GTP and interact with mitoribosomal protein S27. Splice variants differing in the 5′ UTR encode the same protein, and pseudogenes exist on chromosomes 1q and 2q.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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