Thermo Fisher Scientific PRRX1 Monoclonal Antibody (OTI2B2)
PRRX1 단백질을 인식하는 mouse monoclonal antibody로 Western blot 및 IHC(P) 검증 완료. Human 시료에 반응하며, 농도 1 mg/mL의 액상 형태. Affinity Chromatography로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B2 |
| Immunogen | Full length human recombinant protein of PRRX1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725123 |
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species, functioning in DNA binding via a helix-turn-helix structure. It plays a key role in transcriptional regulation and gene expression control.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox DNA-binding domain, belonging to the paired homeobox family.
Localized to the nucleus, PRX1 acts as a transcriptional co-activator enhancing the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression induced by growth and differentiation factors.
Additionally, PRX1 regulates transcriptional activities of creatine kinase-M (muscle), contributing to the establishment of mesodermal muscle types.
PRX1 exists as two alternatively spliced isoforms, PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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