Thermo Fisher Scientific Acetyl-p53 (Lys382) Recombinant Rabbit Monoclonal Antibody
Acetyl-p53 (Lys382) 특이성을 가진 Thermo Fisher의 재조합 토끼 단클론 항체로, 인간 및 생쥐 시료에서 p53 단백질의 아세틸화 상태 검출에 적합합니다. Western blot과 ELISA에 사용 가능하며, 높은 순도와 안정적인 PBS/glycerol 저장 버퍼를 제공합니다.
- 카탈로그번호
- MA542672
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Immunogen | A synthetic acetylated peptide around K382 of human p53 (NP_000537.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2911813 |
Product Specific Information
- Positive test controls: HeLa, NIH/3T3
- Target localization: Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body
- Immunogen sequence: KKGQSTSRHK KLMFKTEGPD S
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation.
p53 up-regulates genes such as p21waf1, promoting G1 or G2/M arrest. Structurally, it includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is linked to tumor formation.
Mutations in p53 are common in human cancers and lead to loss of tumor suppressor activity. Germline mutations of TP53 are associated with Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: MA5-42672_p53_P04637-1_Rabbit.svg, MA5-42672_p53_P04637-1_Rabbit_PDP.jpeg)
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