Thermo Fisher Scientific CRP Recombinant Rabbit Monoclonal Antibody (10J2R8)
Recombinant rabbit monoclonal antibody targeting CRP (Clone 10J2R8). Validated for WB, IHC-P, and ELISA. High specificity for human and mouse CRP. Supplied as liquid, unconjugated form with 0.6 mg/mL concentration. Ideal for inflammation and cardiovasc...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:800 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10J2R8 |
| Immunogen | Synthetic peptide corresponding to amino acids 125–224 of human CRP (P02741) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911815 |
Product Specific Information
Positive test controls include human serum and mouse serum.
Target localization: Secreted.
Immunogen Sequence:
VEFWVDGKPR VRKSLKKGYT VGAEASIILG QEQDSFGGNF EGSQSLVGDI GNVNMWDFVL SPDEINTIYL GGPFSPNVLN WRALKYEVQG EVFTKPQLWP
Target Information
C-reactive protein (CRP) is a major cyclic, pentameric acute-phase protein composed of five identical, noncovalently bound, nonglycosylated subunits. Each subunit consists of 206 amino acids (24 kDa). CRP is produced by the liver and its plasma levels rise dramatically during inflammation. It initiates the classical complement cascade, binds nuclear components (chromatin, histones), and plays a key role in innate immunity. CRP acts as an opsonin, activates monocytes/macrophages, and may function as a scavenger during cell necrosis. Elevated basal CRP levels are associated with increased risk of hypertension and cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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