Thermo Fisher Scientific SGK196 Monoclonal Antibody (OTI3F9), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes a protein involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (α-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens exploit this O-linked carbohydrate unit for host entry.
Loss-of-function compound heterozygous mutations in this gene have been identified in patients with Walker-Warburg syndrome (WWS). Mice lacking this gene exhibit misplaced neurons (heterotopia) in certain brain regions, possibly due to defects in neuronal migration. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.