Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI2B2), TrueMAB

Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI2B2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a secreted, disulfide-linked protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins.
It acts as a cell adhesion molecule in preosteoblasts and plays a role in osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, and is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression increases with bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGFβ1).
The protein includes a signal sequence, a cysteine-rich domain, a fourfold repeated fasciclin-like domain, and a C-terminal domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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