Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI2B2), TrueMAB
인간 Periostin 단백질을 인식하는 Mouse IgG2a 단클론 항체로, WB 및 IHC(P) 실험에 적합. 동결건조 형태로 제공되며, PBS buffer와 trehalose 포함. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Periostin Monoclonal Antibody (OTI2B2), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 538–781 of human POSTN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Periostin (PN), also known as osteoblast-specific factor 2 (OSF-2), is a secreted, disulfide-linked protein that binds heparin and functions as a ligand for α(V)β(3) and α(V)β(5) integrins.
It acts as a cell adhesion molecule in preosteoblasts and plays a role in osteoblast recruitment, spreading, and attachment.
Periostin is mainly detected in the lower gastrointestinal tract, aorta, stomach, placenta, uterus, and breast tissues, and is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer.
Expression increases with bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGFβ1).
The protein includes a signal sequence, a cysteine-rich domain, a fourfold repeated fasciclin-like domain, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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