Thermo Fisher Scientific Caspase 3 Recombinant Superclonal Antibody (22HCLC)
Recombinant Superclonal Caspase 3 antibody for human samples. Offers polyclonal-like sensitivity with monoclonal specificity and lot-to-lot consistency. Suitable for WB and ICC/IF. Rabbit IgG, unconjugated, 0.5 mg/mL in PBS with sodium azide.
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Applications
Western Blot (WB)
- Tested Dilution: 1:100–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Miscellaneous (PubMed)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Clone | 22HCLC |
| Immunogen | Peptide corresponding to amino acids 30–43 of human Casp3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532716 |
Product Specific Information
Recombinant rabbit Superclonal™ antibodies are composed of multiple different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
They recognize multiple epitopes on the target, providing higher detection sensitivity for low-abundance proteins.
Each lot contains a defined mixture of light and heavy chains, ensuring reproducibility and eliminating biological variability.
Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. Product and performance remain unchanged.
Target Information
The Caspase 3 gene encodes a cysteine-aspartic acid protease involved in apoptosis.
Sequential activation of caspases drives cell death processes. Caspase 3 cleaves and activates caspases 6, 7, and 9, and is itself processed by caspases 8, 9, and 10.
It plays a key role in neuronal death associated with Alzheimer’s disease by cleaving amyloid-beta precursor protein.
Alternative splicing produces two transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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