Thermo Fisher Scientific Arginase 1 Recombinant Rabbit Monoclonal Antibody (24H4L3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Cat, and Horse.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that catalyzes the conversion of L-arginine to urea and L-ornithine, completing the urea cycle. The resulting polyamines are crucial for cell proliferation and detoxification.

By degrading arginine, Arginase 1 limits nitric oxide synthesis by depriving NO synthase of its substrate.
In humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSCs), and neural stem cells. Expression is observed in blood neutrophils but not in CCR3+ granulocytes. In mice, it is a hallmark of alternatively activated macrophages (M2a).

Arginase 1 may also be expressed in tumor-infiltrating myeloid cells and is typically found in most hepatocellular carcinomas.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.