Thermo Fisher Scientific OCRL Polyclonal Antibody
Thermo Fisher Scientific의 OCRL Polyclonal Antibody는 인간 및 생쥐 시료에서 OCRL 단백질을 검출하는 토끼 폴리클로날 항체입니다. Western blot과 IHC(P) 실험에 적합하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human OCRL (Accession Q01968), corresponding to amino acid residues Q752–V802 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852523 |
Product Specific Information
This antibody detects endogenous levels of total OCRL.
Target Information
The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, generating second messengers in response to extracellular signals. OCRL1 is a type II 5-phosphatase mutated in the oculocerebrorenal syndrome of Lowe (OCRL), a rare X-linked disorder characterized by congenital cataracts, mental retardation, muscular hypotonia, and renal tubular dysfunction. OCRL1 has high affinity for phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate, and inositol 1,3,4,5-tetrakisphosphate as substrates. It is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), suggesting a role in protein sorting and trafficking within the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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