Thermo Fisher Scientific SCN2A Polyclonal Antibody
SCN2A 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot 및 IHC(파라핀 절편) 분석에 적합하며, 고순도의 Affinity chromatography로 정제되었습니다. -20°C 보관, 연구용 전용 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SCN2A (Accession Q99250), corresponding to amino acid residues Q447–S497 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852517 |
Product Specific Information
Antibody detects endogenous levels of total Na⁺ channel protein type II alpha.
Target Information
Voltage-gated sodium channels are selective ion channels that regulate sodium ion permeability in excitable cells. During action potential propagation, these channels allow sodium influx, causing rapid depolarization.
Type I and III alpha subunits are mainly expressed in neuronal cell bodies and proximal processes, whereas type II alpha subunits are enriched along axons.
Beta1 subunits are expressed in brain, skeletal, and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in pyramidal cells of the deep cerebellar nuclei.
Defects in voltage-gated sodium channels are associated with diseases such as myotonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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