Thermo Fisher Scientific PSMB7 Polyclonal Antibody
PSMB7 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC 등 다양한 응용에 적합. Human 및 Mouse에 반응하며 항원 친화 크로마토그래피로 정제됨. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 85–277 of Human Proteasome 20S beta 7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548462 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HepG2, HCT116, mouse brain
- Predicted reactivity: Mouse (96%), Rat (95%), Dog (95%), Pig (93%), Chicken (84%), Rhesus Monkey (98%), Bovine (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure composed of 4 rings of 28 non-identical subunits (two α and two β rings). Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
The immunoproteasome processes class I MHC peptides. The PSMB7 gene encodes a 20S core β subunit (proteasome B-type family, T1B family). Expression is downregulated by gamma interferon, and proteolytic processing is required for maturation. This subunit is absent in the immunoproteasome, replaced by catalytic subunit 2i (β10).
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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