Thermo Fisher Scientific Glutamine Synthetase Monoclonal Antibody (8G9)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:250

-

Immunoprecipitation (IP)

1-2 µL

-

Product Specifications

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

8G9

Immunogen

Purified, recombinant, human glutamine synthetase protein expressed in E. coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_1074673

Product Specific Information

A suggested positive control for this product is Bosc23 cells transfected with myc-GS.

Target Information

Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. It also has an important role in controlling metabolic regulations of neurotransmitter glutamate. Because of the multiple functions and importance of GS in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of GS is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer`s disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.