Thermo Fisher Scientific SESN1 Polyclonal Antibody
SESN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human과 Mouse에 반응합니다. Western blot과 Flow Cytometry에 적합하며, 고순도의 액상 형태로 제공됩니다. DNA 손상 및 산화 스트레스 연구에 활용 가능합니다.
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Thermo Fisher Scientific SESN1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 312–341 amino acids from the C-terminal region of human Sestrin-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2185472 |
Product Specific Information
This antibody is predicted to react with non-human primate and Xenopus based on sequence homology.
Target Information
The SESN1 gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress.
The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in inhibition of the mammalian target of rapamycin (mTOR) protein.
It also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and its expression is a potential marker for radiation exposure.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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