Thermo Fisher Scientific IGF1R alpha Polyclonal Antibody
IGF1R 알파 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot 및 IHC(P)에서 사용 가능. 인간에 반응하며, 마우스와 랫트에도 예측 반응. 고순도 정제 및 안정적 PBS 버퍼 제공. 연구용으로 세포 성장 및 생존 신호 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 19–51 from the N-terminal region of human IGF1 Receptor (IGF1R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion - Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2122407 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase that mediates the actions of insulin-like growth factor 1 (IGF1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control and is crucial for tumor transformation and survival of malignant cells. Ligand binding activates the receptor kinase, leading to autophosphorylation and phosphorylation of multiple substrates functioning as signaling adapter proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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